Decreased Prevalence of Lymphatic Filariasis among Diabetic Subjects Associated with a Diminished Pro-Inflammatory Cytokine Response (CURES 83)
Identifieur interne : 005957 ( Main/Exploration ); précédent : 005956; suivant : 005958Decreased Prevalence of Lymphatic Filariasis among Diabetic Subjects Associated with a Diminished Pro-Inflammatory Cytokine Response (CURES 83)
Auteurs : Vivekanandhan Aravindhan [Inde] ; Viswanathan Mohan [Inde] ; Jayagopi Surendar [Inde] ; Maradana Muralidhara Rao [Inde] ; Nathella Pavankumar [Inde] ; Mohan Deepa [Inde] ; Ramanujam Rajagopalan [Inde] ; Vasanthapuram Kumaraswami [Inde] ; Thomas B. Nutman [États-Unis] ; Subash Babu [Inde, États-Unis]Source :
- PLoS Neglected Tropical Diseases [ 1935-2727 ] ; 2010.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Anticorps antihelminthe (sang), Antigènes d'helminthe (sang), Cytokines (sang), Diabète de type 2 (parasitologie), Diabète de type 2 (sang), Diabète de type 2 (épidémiologie), Facteurs socioéconomiques, Femelle, Filariose lymphatique (), Filariose lymphatique (parasitologie), Filariose lymphatique (sang), Filariose lymphatique (épidémiologie), Humains, Immunomodulation, Inde (épidémiologie), Interactions hôte-parasite, Modèles logistiques, Mâle, Prévalence, Statistique non paramétrique, Études transversales.
- MESH :
- parasitologie : Diabète de type 2, Filariose lymphatique.
- sang : Anticorps antihelminthe, Antigènes d'helminthe, Cytokines, Diabète de type 2, Filariose lymphatique.
- épidémiologie : Diabète de type 2, Filariose lymphatique, Inde.
- Adulte, Adulte d'âge moyen, Facteurs socioéconomiques, Femelle, Filariose lymphatique, Humains, Immunomodulation, Interactions hôte-parasite, Modèles logistiques, Mâle, Prévalence, Statistique non paramétrique, Études transversales.
- Wicri :
- geographic : Inde.
English descriptors
- KwdEn :
- Adult, Antibodies, Helminth (blood), Antigens, Helminth (blood), Cross-Sectional Studies, Cytokines (blood), Diabetes Mellitus, Type 2 (blood), Diabetes Mellitus, Type 2 (epidemiology), Diabetes Mellitus, Type 2 (parasitology), Elephantiasis, Filarial (blood), Elephantiasis, Filarial (complications), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (parasitology), Female, Host-Parasite Interactions, Humans, Immunomodulation, India (epidemiology), Logistic Models, Male, Middle Aged, Prevalence, Socioeconomic Factors, Statistics, Nonparametric.
- MESH :
- chemical , blood : Antibodies, Helminth, Antigens, Helminth, Cytokines.
- geographic , epidemiology : India.
- blood : Diabetes Mellitus, Type 2, Elephantiasis, Filarial.
- complications : Elephantiasis, Filarial.
- epidemiology : Diabetes Mellitus, Type 2, Elephantiasis, Filarial.
- parasitology : Diabetes Mellitus, Type 2, Elephantiasis, Filarial.
- Adult, Cross-Sectional Studies, Female, Host-Parasite Interactions, Humans, Immunomodulation, Logistic Models, Male, Middle Aged, Prevalence, Socioeconomic Factors, Statistics, Nonparametric.
Abstract
Epidemiological studies have shown an inverse correlation between the incidence of lymphatic filariasis (LF) and the incidence of allergies and autoimmunity. However, the interrelationship between LF and type-2 diabetes is not known and hence, a cross sectional study to assess the baseline prevalence and the correlates of sero-positivity of LF among diabetic subjects was carried out (n = 1416) as part of the CURES study. There was a significant decrease in the prevalence of LF among diabetic subjects (both newly diagnosed [5.7%] and those under treatment [4.3%]) compared to pre-diabetic subjects [9.1%] (p = 0.0095) and non-diabetic subjects [10.4%] (p = 0.0463). A significant decrease in filarial antigen load (p = 0.04) was also seen among diabetic subjects. Serum cytokine levels of the pro-inflammatory cytokines—IL-6 and GM-CSF—were significantly lower in diabetic subjects who were LF positive, compared to those who were LF negative. There were, however, no significant differences in the levels of anti-inflammatory cytokines—IL-10, IL-13 and TGF-β—between the two groups. Although a direct causal link has yet to be shown, there appears to be a striking inverse relationship between the prevalence of LF and diabetes, which is reflected by a diminished pro-inflammatory cytokine response in Asian Indians with diabetes and concomitant LF.
Url:
DOI: 10.1371/journal.pntd.0000707
PubMed: 20559443
PubMed Central: 2886036
Affiliations:
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Le document en format XML
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Nutman</name><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Babu, Subash" sort="Babu, Subash" uniqKey="Babu S" first="Subash" last="Babu">Subash Babu</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>National Institutes of Health-International Center for Excellence in Research, Chennai, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>National Institutes of Health-International Center for Excellence in Research, Chennai</wicri:regionArea><wicri:noRegion>Chennai</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><series><title level="j">PLoS Neglected Tropical Diseases</title><idno type="ISSN">1935-2727</idno><idno type="eISSN">1935-2735</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antibodies, Helminth (blood)</term><term>Antigens, Helminth (blood)</term><term>Cross-Sectional Studies</term><term>Cytokines (blood)</term><term>Diabetes Mellitus, Type 2 (blood)</term><term>Diabetes Mellitus, Type 2 (epidemiology)</term><term>Diabetes Mellitus, Type 2 (parasitology)</term><term>Elephantiasis, Filarial (blood)</term><term>Elephantiasis, Filarial (complications)</term><term>Elephantiasis, Filarial (epidemiology)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Female</term><term>Host-Parasite Interactions</term><term>Humans</term><term>Immunomodulation</term><term>India (epidemiology)</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Prevalence</term><term>Socioeconomic Factors</term><term>Statistics, Nonparametric</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anticorps antihelminthe (sang)</term><term>Antigènes d'helminthe (sang)</term><term>Cytokines (sang)</term><term>Diabète de type 2 (parasitologie)</term><term>Diabète de type 2 (sang)</term><term>Diabète de type 2 (épidémiologie)</term><term>Facteurs socioéconomiques</term><term>Femelle</term><term>Filariose lymphatique ()</term><term>Filariose lymphatique (parasitologie)</term><term>Filariose lymphatique (sang)</term><term>Filariose lymphatique (épidémiologie)</term><term>Humains</term><term>Immunomodulation</term><term>Inde (épidémiologie)</term><term>Interactions hôte-parasite</term><term>Modèles logistiques</term><term>Mâle</term><term>Prévalence</term><term>Statistique non paramétrique</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Helminth</term><term>Antigens, Helminth</term><term>Cytokines</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>India</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Diabetes Mellitus, Type 2</term><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Diabetes Mellitus, Type 2</term><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Diabète de type 2</term><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Diabetes Mellitus, Type 2</term><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Antigènes d'helminthe</term><term>Cytokines</term><term>Diabète de type 2</term><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Diabète de type 2</term><term>Filariose lymphatique</term><term>Inde</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cross-Sectional Studies</term><term>Female</term><term>Host-Parasite Interactions</term><term>Humans</term><term>Immunomodulation</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Prevalence</term><term>Socioeconomic Factors</term><term>Statistics, Nonparametric</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs socioéconomiques</term><term>Femelle</term><term>Filariose lymphatique</term><term>Humains</term><term>Immunomodulation</term><term>Interactions hôte-parasite</term><term>Modèles logistiques</term><term>Mâle</term><term>Prévalence</term><term>Statistique non paramétrique</term><term>Études transversales</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Inde</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Epidemiological studies have shown an inverse correlation between the incidence of lymphatic filariasis (LF) and the incidence of allergies and autoimmunity. However, the interrelationship between LF and type-2 diabetes is not known and hence, a cross sectional study to assess the baseline prevalence and the correlates of sero-positivity of LF among diabetic subjects was carried out (n = 1416) as part of the CURES study. There was a significant decrease in the prevalence of LF among diabetic subjects (both newly diagnosed [5.7%] and those under treatment [4.3%]) compared to pre-diabetic subjects [9.1%] (p = 0.0095) and non-diabetic subjects [10.4%] (p = 0.0463). A significant decrease in filarial antigen load (p = 0.04) was also seen among diabetic subjects. Serum cytokine levels of the pro-inflammatory cytokines—IL-6 and GM-CSF—were significantly lower in diabetic subjects who were LF positive, compared to those who were LF negative. There were, however, no significant differences in the levels of anti-inflammatory cytokines—IL-10, IL-13 and TGF-β—between the two groups. Although a direct causal link has yet to be shown, there appears to be a striking inverse relationship between the prevalence of LF and diabetes, which is reflected by a diminished pro-inflammatory cytokine response in Asian Indians with diabetes and concomitant LF.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Joshi, Sr" uniqKey="Joshi S">SR Joshi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muller, Lm" uniqKey="Muller L">LM Muller</name></author><author><name sortKey="Gorter, Kj" uniqKey="Gorter K">KJ Gorter</name></author><author><name sortKey="Hak, E" uniqKey="Hak E">E Hak</name></author><author><name sortKey="Goudzwaard, Wl" uniqKey="Goudzwaard W">WL Goudzwaard</name></author><author><name sortKey="Schellevis, Fg" uniqKey="Schellevis F">FG Schellevis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Talaat, Kr" uniqKey="Talaat K">KR 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sortKey="Kumaraswami, Vasanthapuram" sort="Kumaraswami, Vasanthapuram" uniqKey="Kumaraswami V" first="Vasanthapuram" last="Kumaraswami">Vasanthapuram Kumaraswami</name><name sortKey="Mohan, Viswanathan" sort="Mohan, Viswanathan" uniqKey="Mohan V" first="Viswanathan" last="Mohan">Viswanathan Mohan</name><name sortKey="Mohan, Viswanathan" sort="Mohan, Viswanathan" uniqKey="Mohan V" first="Viswanathan" last="Mohan">Viswanathan Mohan</name><name sortKey="Muralidhara Rao, Maradana" sort="Muralidhara Rao, Maradana" uniqKey="Muralidhara Rao M" first="Maradana" last="Muralidhara Rao">Maradana Muralidhara Rao</name><name sortKey="Pavankumar, Nathella" sort="Pavankumar, Nathella" uniqKey="Pavankumar N" first="Nathella" last="Pavankumar">Nathella Pavankumar</name><name sortKey="Rajagopalan, Ramanujam" sort="Rajagopalan, Ramanujam" uniqKey="Rajagopalan R" first="Ramanujam" last="Rajagopalan">Ramanujam Rajagopalan</name><name sortKey="Surendar, Jayagopi" sort="Surendar, Jayagopi" uniqKey="Surendar J" first="Jayagopi" last="Surendar">Jayagopi Surendar</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. 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